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KMID : 1123920030170051321
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 5 p.1321 ~ p.1324
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Antimalarial activity of marine alga aganist P. falciparum in vitro
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Kim Hye-Sook
Takaya Yoshiaki
Ahnn Joo-Hong
Jeon Byung-Hoon
Shin Ho-Joon
Shin Chang-Ho
Kim Yong-Man
Park Hyun
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Abstract
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To produce anti-malarial drugs, natural products were extracted from 18 species of marine algae by various mechanical methods. Twelve species of marine algae were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC/sub 50/ values less than 100 ㎍/㎖. The methanol extract of Neoholmeria japonica had the strongest antiplasmodial activity with EC/sub 50/ value of 62 ㎍/㎖.
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KEYWORD
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Plasmodium falciparum, Neoholmeria japonica, antiplasmodial activity
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